id,agency_id,docket_id,title,document_type,subtype,posted_date,posted_year,posted_month,comment_start_date,comment_end_date,last_modified,fr_doc_num,open_for_comment,withdrawn,object_id EPA-R01-SFUND-2026-0826-0014,EPA,EPA-R01-SFUND-2026-0826,REDACTED 2020 ANNUAL REPORT - OPERABLE UNIT (OU) 1,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:32Z,,0,0,09000064b92d874b EPA-R01-SFUND-2026-0826-0006,EPA,EPA-R01-SFUND-2026-0826,FINAL 2025 ANNUAL REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:31Z,,0,0,09000064b92d8739 EPA-HQ-OPPT-2018-0465-0072,EPA,EPA-HQ-OPPT-2018-0465,"September 10, 2024 Amended Final Report TDCE Abiotic Feasibility Study submitted by BCCM",Supporting & Related Material,Report,2026-05-15T04:00:00Z,2026,5,,,2026-05-16T01:40:23Z,,0,0,09000064b92d9dcf EPA-R01-SFUND-2026-0826-0003,EPA,EPA-R01-SFUND-2026-0826,FINAL TECHNICAL MEMORANDUM PROPOSED ALTERNATIVE REMEDY,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:30Z,,0,0,09000064b92d8736 EPA-R01-SFUND-2026-0826-0010,EPA,EPA-R01-SFUND-2026-0826,ROOT CAUSE ANALYSIS AND MONITORIING NETWORK EVALUATION INSTALLATION OF DEEP BEDROCK MONITORING WELLS,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:32Z,,0,0,09000064b92d873d EPA-R01-SFUND-2026-0826-0008,EPA,EPA-R01-SFUND-2026-0826,DRAFT FINAL FOCUSED FEASIBILITY STUDY (FS) REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:31Z,,0,0,09000064b92d873b EPA-R01-SFUND-2026-0826-0007,EPA,EPA-R01-SFUND-2026-0826,SAVAGE MUNICIPAL WATER SUPPLY OPERABLE UNIT (OU) 1 DRAFT THIRD EXPLANATION OF SIGNIFICANT DIFFERENCES (ESD) FOR P,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:31Z,,0,0,09000064b92d873a EPA-R01-SFUND-2026-0826-0011,EPA,EPA-R01-SFUND-2026-0826,THIRD FIVE-YEAR REVIEW REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:32Z,,0,0,09000064b92d8748 EPA-R01-SFUND-2026-0826-0004,EPA,EPA-R01-SFUND-2026-0826,FINAL FOCUSED FEASIBILITY STUDY (FFS) REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:30Z,,0,0,09000064b92d8737 EPA-R01-SFUND-2026-0826-0012,EPA,EPA-R01-SFUND-2026-0826,REDACTED REMEDIAL INVESTIGATION (RI) REPORT ADDENDUM FOR TECHNICAL IMPRACTICABILITY (TI) ZONE BEDROCK,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:32Z,,0,0,09000064b92d8749 EPA-R01-SFUND-2026-0826-0002,EPA,EPA-R01-SFUND-2026-0826,FINAL PERMEABLE REACTIVE BARRIER CONCEPTUAL DESIGN REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:30Z,,0,0,09000064b92d8735 EPA-R01-SFUND-2026-0826-0015,EPA,EPA-R01-SFUND-2026-0826,REDACTED FINAL 2010 ANNUAL REPORT - OPERABLE UNIT (OU) 1,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:32Z,,0,0,09000064b92d874c EPA-R01-SFUND-2026-0826-0013,EPA,EPA-R01-SFUND-2026-0826,REDACTED FINAL 2024 ANNUAL REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:32Z,,0,0,09000064b92d874a EPA-R01-SFUND-2026-0826-0009,EPA,EPA-R01-SFUND-2026-0826,ANNUAL REPORT FOR 2008 (03172010 TRANSMITTAL LETTER ATTACHED),Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:31Z,,0,0,09000064b92d873c EPA-R01-SFUND-2026-0826-0005,EPA,EPA-R01-SFUND-2026-0826,FINAL PRE-REMEDIAL DESIGN INVESTIGATION REPORT,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T17:14:31Z,,0,0,09000064b92d8738 FWS-HQ-IA-2026-0298-0003,FWS,FWS-HQ-IA-2026-0298,"Applicant: George Sammut, Morgan Hill, CA; Permit No. PER26821388",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:00Z,,0,0,09000064b92d957b FWS-HQ-IA-2026-0298-0009,FWS,FWS-HQ-IA-2026-0298,"Applicant: St. Augustine Alligator Farm, St. Augustine, FL; Permit No. PER21244411",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:02Z,,0,0,09000064b92d9581 FWS-HQ-IA-2026-0298-0011,FWS,FWS-HQ-IA-2026-0298,"Applicant: St. Augustine Alligator Farm, St. Augustine, FL; Permit No. PER21244412",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:02Z,,0,0,09000064b92d95a1 FWS-HQ-IA-2026-0298-0005,FWS,FWS-HQ-IA-2026-0298,"Applicant: Craig Keller, Tunkhannock, PA; Permit No. PER25338256",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:01Z,,0,0,09000064b92d957d FWS-HQ-IA-2026-0298-0002,FWS,FWS-HQ-IA-2026-0298,"Applicant: Stephen Isenhour, Hickory, NC; Permit No. PER26245661",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:00Z,,0,0,09000064b92d957a FWS-HQ-IA-2026-0298-0010,FWS,FWS-HQ-IA-2026-0298,"Applicant: Collin Griffiths, Missoula, MT; Permit No. PER26935891",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:02Z,,0,0,09000064b92d95a0 FWS-HQ-IA-2026-0298-0007,FWS,FWS-HQ-IA-2026-0298,"Applicant: Brandon Isenhour, Hickory, NC; Permit No. PER26245660",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:01Z,,0,0,09000064b92d957f FWS-HQ-IA-2026-0298-0013,FWS,FWS-HQ-IA-2026-0298,"Applicant: Henry Vilas Zoo, Madison, WI; Permit No. PER27541931",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:03Z,,0,0,09000064b92d95a3 FWS-R5-FAC-2026-1684-0004,FWS,FWS-R5-FAC-2026-1684,FWS Form 3-2493 American Shad Recapture Data draft Rev 07-2017,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:48:12Z,,0,0,09000064b92d9025 FWS-HQ-IA-2026-0298-0004,FWS,FWS-HQ-IA-2026-0298,"Applicant: Charlie Dally, Rathdrum, ID; Permit No. PER27974123",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:00Z,,0,0,09000064b92d957c FWS-HQ-IA-2026-0298-0006,FWS,FWS-HQ-IA-2026-0298,"Applicant: Sam Noble Oklahoma Museum of Natural History, Norman, OK; Permit No. PER25540581",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:01Z,,0,0,09000064b92d957e FWS-HQ-IA-2026-0298-0008,FWS,FWS-HQ-IA-2026-0298,"Applicant: Vicki Lynn Lee, Ft. Collins, CO; Permit No. PER26618348",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:02Z,,0,0,09000064b92d9580 FWS-HQ-IA-2026-0298-0012,FWS,FWS-HQ-IA-2026-0298,"Applicant: Turtle Conservancy, Ojai, CA; Permit No. PER27229456",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:03Z,,0,0,09000064b92d95a2 FWS-R5-FAC-2026-1684-0005,FWS,FWS-R5-FAC-2026-1684,FWS Form 3-2310 Horseshoe Crab Recapture Report Rev 07-2017,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:48:14Z,,0,0,09000064b92d9026 FWS-R5-FAC-2026-1684-0007,FWS,FWS-R5-FAC-2026-1684,FWS Form 3-2311 Horseshoe Crab Tagging Report Rev 07-2017,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:48:16Z,,0,0,09000064b92d9035 FWS-R5-FAC-2026-1684-0003,FWS,FWS-R5-FAC-2026-1684,FWS Form 3-2496 Sturgeon Recapture Data Rev 07-2017,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:48:11Z,,0,0,09000064b92d9024 FWS-R5-FAC-2026-1684-0002,FWS,FWS-R5-FAC-2026-1684,FWS Form 3-2495 Striped Bass Recapture Data Rev 07-2017,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:48:09Z,,0,0,09000064b92d9023 FWS-HQ-IA-2026-0298-0016,FWS,FWS-HQ-IA-2026-0298,"Applicant: John Ball Zoo, Grand Rapids, MN; Permit No. PER27754098",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:04Z,,0,0,09000064b92d95a6 FWS-HQ-IA-2026-0298-0015,FWS,FWS-HQ-IA-2026-0298,"Applicant: Turtle Survival Alliance, North Charleston, SC; Permit No. PER27332264",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:03Z,,0,0,09000064b92d95a5 FWS-R5-FAC-2026-1684-0006,FWS,FWS-R5-FAC-2026-1684,FWS Form 3-2494 Snakehead Recapture Data Rev 07-2017,Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:48:15Z,,0,0,09000064b92d9027 FWS-HQ-IA-2026-0298-0014,FWS,FWS-HQ-IA-2026-0298,"Applicant: Minnesota Zoo, Apple Valley, MN; Permit No. PER26188753",Supporting & Related Material,,2026-05-15T04:00:00Z,2026,5,,,2026-05-15T16:54:03Z,,0,0,09000064b92d95a4 EPA-R05-OAR-2025-3654-0014,EPA,EPA-R05-OAR-2025-3654,"On-road Testing Contract for Enhanced Inspection and Maintenance (I/M) Programs under Ohio's Ozone Attainment Demonstration for the Cleveland, OH 2015 Serious Ozone Nonattainment Area",Supporting & Related Material,State/Tribal Submittal,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T18:51:31Z,,0,0,09000064b92d86c4 EPA-R09-OAR-2026-2608-0006,EPA,EPA-R09-OAR-2026-2608,NPRM Docket Index_Portola CDD DAAD,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T21:20:32Z,,0,0,09000064b92d8fa4 EPA-R10-RCRA-2026-2146-0003,EPA,EPA-R10-RCRA-2026-2146,AK.Statutes.and.Regulations_FRL.13305-01-R10_NPRM,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:11Z,,0,0,09000064b92d1f51 EPA-R05-OAR-2025-3654-0013,EPA,EPA-R05-OAR-2025-3654,Cleveland Attainment Demonstration SIGNED_DATED -R5 transmittal letter,Supporting & Related Material,State/Tribal Submittal,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T18:51:29Z,,0,0,09000064b92d868f EPA-R09-OAR-2026-2608-0003,EPA,EPA-R09-OAR-2026-2608,"B. State Plans, Support Documents, Reports, and Correspondence",Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T21:20:25Z,,0,0,09000064b92d8f66 EPA-HQ-OPP-2025-0177-0010,EPA,EPA-HQ-OPP-2025-0177,Product label: Construct CTV-SoD2-1,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:39:23Z,,0,0,09000064b92cf35b EPA-HQ-OPP-2025-0177-0007,EPA,EPA-HQ-OPP-2025-0177,"Product Characterization and Human Health Risk Assessment for Citrus tristeza virus (CTV) strain T36 expressing Spinach Defensin Proteins (SoD) 2, 2-1, and 2* (March 26, 2026)",Supporting & Related Material,Data,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:39:22Z,,0,0,09000064b92cf32b EPA-HQ-OPP-2025-0177-0012,EPA,EPA-HQ-OPP-2025-0177,"Proposed Registration Decision for the New Microbial Pesticide Active Ingredients: Citrus tristeza virus (CTV) strain T36 expressing Spinach Defensin Protein SoD2, Citrus tristeza virus (CTV) strain T36 expressing Spinach Defensin Protein SoD2-1, and Citrus tristeza virus (CTV) strain T36 expressing Spinach Defensin Protein SoD2*",Supporting & Related Material,Decision,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:39:23Z,,0,0,09000064b92d0205 EPA-R10-OAR-2026-0694-0003,EPA,EPA-R10-OAR-2026-0694,002_5-26-17 Opinion Letter-attachments condensed,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:13:33Z,,0,0,09000064b9187ea4 EPA-R10-RCRA-2026-2146-0006,EPA,EPA-R10-RCRA-2026-2146,AK.State Public Comment Process_FRL.13305-01-R10_NPRM,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:19Z,,0,0,09000064b92d1f24 EPA-R10-RCRA-2026-2146-0007,EPA,EPA-R10-RCRA-2026-2146,AK.Governor Transmittal 02.24.2026_FRL13305-01-R10_NPRM,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:23Z,,0,0,09000064b92d1f23 EPA-R10-RCRA-2026-2146-0002,EPA,EPA-R10-RCRA-2026-2146,AK.Program Description_FRL.13305-01-R10_NPRM,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:08Z,,0,0,09000064b92d1f52 EPA-R10-OAR-2026-0694-0004,EPA,EPA-R10-OAR-2026-0694,001_NWCAA SSI Request for Delegation,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:13:41Z,,0,0,09000064b9187ea3 EPA-R10-OAR-2026-0694-0005,EPA,EPA-R10-OAR-2026-0694,003_TSD NWCAA SSI plan,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:13:48Z,,0,0,09000064b9187ea2 EPA-R10-RCRA-2026-2146-0005,EPA,EPA-R10-RCRA-2026-2146,AK_Attorney.Generals.Statement_FRL13305-01-R10_NPRM,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:16Z,,0,0,09000064b92d1f4f EPA-HQ-OPP-2025-0177-0009,EPA,EPA-HQ-OPP-2025-0177,Product label: Construct CTV-SoD2,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:39:23Z,,0,0,09000064b92cf35a EPA-HQ-OPP-2025-0177-0011,EPA,EPA-HQ-OPP-2025-0177,Product label: Construct CTV-SoD2*,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:39:23Z,,0,0,09000064b92cf3be EPA-R09-OAR-2026-2608-0004,EPA,EPA-R09-OAR-2026-2608,C. Additional Documents for Proposed Rulemaking,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T21:20:28Z,,0,0,09000064b92d8f80 EPA-R09-OAR-2026-2608-0002,EPA,EPA-R09-OAR-2026-2608,"A. U.S. EPA Guidance Documents, Policies, and Rulemakings",Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T21:20:23Z,,0,0,09000064b92d7394 EPA-HQ-OPPT-2025-3358-0007,EPA,EPA-HQ-OPPT-2025-3358,Biographies of interested and available candidates under consideration for selection as ad hoc peer reviewers for the SACC peer review of selected TSCA-designated High-Priority chemicals undergoing risk evaluation in Mid-2026,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-15T02:14:29Z,,0,0,09000064b92d9d74 EPA-HQ-OPP-2025-0177-0008,EPA,EPA-HQ-OPP-2025-0177,"Environmental Risk Assessment for the New Active Ingredients Spinach Defensin Protein 2 (GE CTV-SoD2, CTV-SoD2-1, and CTV-SoD2*) as Expressed in Genetically Engineered Citrus Tristeza Virus Strain T36 Isolates. Data and Information Were Provided in Support of Applications for FIFRA Section 3 End Use Registrations",Supporting & Related Material,Risk Assessment,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:39:23Z,,0,0,09000064b92cf33b EPA-R10-OAR-2026-0694-0002,EPA,EPA-R10-OAR-2026-0694,004_MoA_NWCAA_p62_LLL_2018,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T16:52:25Z,,0,0,09000064b9187ea1 EPA-R10-RCRA-2026-2146-0001,EPA,EPA-R10-RCRA-2026-2146,Notice of Completeness Determination for Alaska RCRA Subtitle C Program Authorization,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:03Z,,0,0,09000064b92d46e9 EPA-R10-RCRA-2026-2146-0004,EPA,EPA-R10-RCRA-2026-2146,AK.EPA_Memorandum_Agreement_FRL.13305-01-R10_NPRM,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T20:17:13Z,,0,0,09000064b92d1f50 EPA-R09-OAR-2026-2608-0005,EPA,EPA-R09-OAR-2026-2608,D. Notice of Proposed Rulemaking,Supporting & Related Material,,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T21:20:30Z,,0,0,09000064b92d8f9a EPA-HQ-SFUND-2015-0100-0035,EPA,EPA-HQ-SFUND-2015-0100,Supporting Statement 2050-0086 1445.16 2022 508,Supporting & Related Material,ICR Supporting Statement,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T21:17:55Z,,0,0,09000064b92d3d9d FDA-2026-P-5454-0009,FDA,FDA-2026-P-5454,"References 7 - Smarr, M. M., et al. (2016). Urinary paracetamol and time-to-pregnancy. Human Reproduction, 31(9), 2119-2127. URL: https://pubmed.ncbi.nlm.nih.gov/27412248/",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:39Z,,0,0,09000064b92d5011 FDA-2026-P-5454-0014,FDA,FDA-2026-P-5454,"Reference 12 - de Araújo-Ramos, A. T., et al. (2026). Differential disruption of gonadal development by DEHP and paracetamol in male and female Wistar rats. Reproductive Toxicology, 141, 109183. URL: https://doi.org/10.1016/j.reprotox.2026.109183",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:56Z,,0,0,09000064b92d5031 FDA-2026-P-5454-0015,FDA,FDA-2026-P-5454,"Reference 13 - Laursen, T. Q., et al. (2024). Maternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons. Reproductive Toxicology, 127, 108626. URL: https://doi.org/10.1016/j.reprotox.2024.108626",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:00Z,,0,0,09000064b92d5032 FDA-2026-P-5454-0011,FDA,FDA-2026-P-5454,"Reference 9 - Carlsen, L. N., et al. (2024). Overuse of analgesics can affect the fertility biomarker Anti-Müllerian Hormone in females. A translational study. Cephalalgia, 44(11). URL: https://doi.org/10.1177/03331024241290530",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:46Z,,0,0,09000064b92d5013 FDA-2026-P-5454-0004,FDA,FDA-2026-P-5454,"References 2 - Fisher, B. G., et al. (2016). Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants. Human Reproduction, 31(11), 2642-2650. URL: https://pubmed.ncbi.nlm.nih.gov/27609981/",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:41:58Z,,0,0,09000064b92d500c FDA-2026-P-5454-0013,FDA,FDA-2026-P-5454,"Reference 11 - Wu, T., et al. (2024). Prenatal acetaminophen exposure and the developing ovary: time, dose, and course consequences for fetal mice. Food and Chemical Toxicology, 189, 114679. URL: https://doi.org/10.1016/j.fct.2024.114679",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:53Z,,0,0,09000064b92d5030 FDA-2026-P-5578-0004,FDA,FDA-2026-P-5578,Attachment 2,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T23:18:09Z,,0,0,09000064b92d70f1 FDA-2026-P-5578-0005,FDA,FDA-2026-P-5578,Attachment 3,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T23:18:14Z,,0,0,09000064b92d70f2 FDA-2026-P-5454-0017,FDA,FDA-2026-P-5454,"Reference 15 - Lee, C. Y., et al. (2023). Effects of acetaminophen on reproductive activities in male golden hamsters. Development & Reproduction, 27(1), 25-37. URL: https://doi.org/10.12717/DR.2023.27.1.25",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:26Z,,0,0,09000064b92d5034 FDA-2026-P-5611-0003,FDA,FDA-2026-P-5611,attachment-1-orange-book-page,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T23:37:59Z,,0,0,09000064b92d874f FDA-2026-P-5454-0021,FDA,FDA-2026-P-5454,"Reference 19 - Eletri, L., et al. (2026). Association between in utero exposure to acetaminophen and external genital tract malformations in boys and girls: a systematic review and meta-analysis. Human Reproduction, 41(3), 427-442. URL: https://doi.org/10.1093/humrep/deaf253",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:53Z,,0,0,09000064b92d5038 FDA-2026-P-5454-0003,FDA,FDA-2026-P-5454,"References 1 - Ernstsen, C., et al. (2026). Prenatal paracetamol modulates sexually dimorphic behaviour and steroidogenesis in adult male and female mice. Reproduction, 171(2). URL: https://doi.org/10.1093/reprod/xaag007",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:41:54Z,,0,0,09000064b92d500b FDA-2026-P-5454-0006,FDA,FDA-2026-P-5454,"References 4 - Guzmán-Montemayor, A. J., et al. (2026). Prenatal, but not neonatal, paracetamol exposure disrupts neuroendocrine regulation of stress and emotional behavior in adult male rats. Physiology & Behavior, 308, 115261. URL: https://doi.org/10.1016/j.physbeh.2026.115261",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:16Z,,0,0,09000064b92d500e FDA-2026-P-5454-0007,FDA,FDA-2026-P-5454,"References 5 - Górawski, F., et al. (2026). Sex-dependent effects of early-life paracetamol exposure on behavior and monoamines in the rat central nervous system. Chemico-Biological Interactions, 427, 111937. URL: https://doi.org/10.1016/j.cbi.2026.111937",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:31Z,,0,0,09000064b92d500f FDA-2026-P-5611-0004,FDA,FDA-2026-P-5611,attachment-2-rld-labeling,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T23:38:03Z,,0,0,09000064b92d8750 FDA-2026-P-5611-0005,FDA,FDA-2026-P-5611,attachment-3-test-product-draft-labeling,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T23:38:07Z,,0,0,09000064b92d8751 FDA-2026-P-5454-0005,FDA,FDA-2026-P-5454,"Reference 3 - Lind, D. V., et al. (2017). Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons. Human Reproduction, 32(1), 149-155. URL: https://pubmed.ncbi.nlm.nih.gov/27852690/",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:12Z,,0,0,09000064b92d500d FDA-2026-P-5454-0018,FDA,FDA-2026-P-5454,"Reference 16 - Xu, M., et al. (2024). Association of acetaminophen use with perinatal outcomes among pregnant women: a retrospective cohort study with propensity score matching. BMC Pregnancy and Childbirth, 24, 268. URL: https://doi.org/10.1186/s12884-024-06480-5",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:29Z,,0,0,09000064b92d5035 FDA-2026-P-5454-0023,FDA,FDA-2026-P-5454,Reference 21 - OFIRMEV (acetaminophen) Injection Package Insert. (2018). Mallinckrodt Hospital Products Inc.,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:44:02Z,,0,0,09000064b92d503a FDA-2026-P-5454-0020,FDA,FDA-2026-P-5454,"Reference 18 - Rehfeld, A., et al. (2022). Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism. Human Reproduction, 37(5), 922-935. URL: https://doi.org/10.1093/humrep/deac042",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:48Z,,0,0,09000064b92d5037 FDA-2026-P-5454-0022,FDA,FDA-2026-P-5454,"Reference 20 - Kougias, D. G., et al. (2025). A quantitative weight-of-evidence review of preclinical studies examining the potential developmental and reproductive toxicity of acetaminophen. Critical Reviews in Toxicology, 55(2), 179-226. URL: https://doi.org/10.1080/10408444.2024.2446471",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:58Z,,0,0,09000064b92d5039 FDA-2026-P-5454-0010,FDA,FDA-2026-P-5454,"References 8 - Nielsen, B. S., et al. (2025). Paracetamol disrupts early embryogenesis by cell cycle inhibition. Human Reproduction, 40(10), 1860-1876. URL: https://doi.org/10.1093/humrep/deaf116",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:42Z,,0,0,09000064b92d5012 FDA-2026-P-5454-0019,FDA,FDA-2026-P-5454,"Reference 17 - Zafeiri, A., et al. (2022). Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151,141 singleton pregnancies. BMJ Open, 12(5), e048092. URL: https://doi.org/10.1136/bmjopen-2020-048092",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:32Z,,0,0,09000064b92d5036 FDA-2026-P-5454-0008,FDA,FDA-2026-P-5454,"References 6 - Lecante, L. L., et al. (2022). Acetaminophen interferes with the first trimester human fetal ovary development in an ex vivo model. Journal of Clinical Endocrinology & Metabolism, 107(6), 1647-1661. URL: https://pubmed.ncbi.nlm.nih.gov/35147701/",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:35Z,,0,0,09000064b92d5010 FDA-2026-P-5454-0012,FDA,FDA-2026-P-5454,"Reference 10 - Liu, F., et al. (2024). Maternal administration of acetaminophen affects meiosis through its metabolite NAPQI targeting SIRT7 in fetal oocytes. Antioxidants & Redox Signaling, 41, 93-109. URL: https://doi.org/10.1089/ars.2023.0270",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:42:50Z,,0,0,09000064b92d502f FDA-2026-P-5454-0016,FDA,FDA-2026-P-5454,"Reference 14 - Andreasen, S. M., et al. (2025). Maternal urinary paracetamol concentrations and self-reported paracetamol use in mid-gestation: association to reduced anogenital distance in offspring from infancy to 9 years. Reproductive Toxicology, 135, 108946. URL: https://pubmed.ncbi.nlm.nih.gov/40374128/",Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T17:43:22Z,,0,0,09000064b92d5033 FDA-2026-P-5578-0003,FDA,FDA-2026-P-5578,Attachment 1,Supporting & Related Material,Background Material,2026-05-14T04:00:00Z,2026,5,,,2026-05-14T23:18:06Z,,0,0,09000064b92d70f0 EPA-HQ-OAR-2025-0618-0023,EPA,EPA-HQ-OAR-2025-0618,"Letter from E. Stuart, Steel Manufacturers Association to EPA",Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:07Z,,0,0,09000064b92c3ba9 EPA-HQ-OAR-2025-0618-0013,EPA,EPA-HQ-OAR-2025-0618,"Letter from B. Stout, BP America, Inc. to Department of Commerce",Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:05Z,,0,0,09000064b92c4a21 EPA-HQ-OPPT-2018-0458-0073,EPA,EPA-HQ-OPPT-2018-0458,TPP Dermal OECD428 ACC Final Study Report EPA Response 15 July 25,Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T18:35:52Z,,0,0,09000064b92c7f74 EPA-HQ-OAR-2025-0618-0017,EPA,EPA-HQ-OAR-2025-0618,"Letter from C. Fitzsimmons, Iowa Department of Natural Resources (DNR) to EPA",Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:05Z,,0,0,09000064b92c1c28 EPA-HQ-OAR-2025-0618-0020,EPA,EPA-HQ-OAR-2025-0618,Letter from The National Environmental Development Association’s Clean Air Project (NEDACAP) to Department of Commerce,Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:06Z,,0,0,09000064b92c3b43 EPA-HQ-OAR-2025-0618-0007,EPA,EPA-HQ-OAR-2025-0618,"Memorandum from J. Rasnic, EPA/OAQPS, to B. Turlinski, EPA Region III. Construction Activities at Georgia Pacific",Supporting & Related Material,Memorandum,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:03Z,,0,0,09000064b92c49b7 EPA-HQ-OAR-2025-0618-0009,EPA,EPA-HQ-OAR-2025-0618,"Memorandum from A. Idsal, EPA Principal Deputy Assistant Administrator, to Regional Air Division Directors. Interpretation of “Begin Actual Construction” Under the New Source Review Preconstruction Permitting Regulations. March 2020, Draft Memo",Supporting & Related Material,Memorandum,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:04Z,,0,0,09000064b92c49d0 EPA-HQ-OAR-2025-0618-0010,EPA,EPA-HQ-OAR-2025-0618,"Comments of the American Chemistry Council, American Forest & Paper Association, American Fuel & Petrochemical Manufacturers, American Petroleum Institute, American Wood Council, National Oilseed Processors Association, Portland Cement Association, Air Permitting Forum, and Auto Industry Forum on Draft Guidance on Interpretation of “Begin Actual Construction”",Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:04Z,,0,0,09000064b92c49fa EPA-HQ-OPPT-2018-0462-0080,EPA,EPA-HQ-OPPT-2018-0462,TBBPA Consumer Exposure Protocol 6 and 9 ACC Final Study Report EPA Response 10 March 26,Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T18:36:50Z,,0,0,09000064b92c837d EPA-HQ-OAR-2025-0618-0015,EPA,EPA-HQ-OAR-2025-0618,"Letter from R. Singhal, Flexible Packaging Association to EPA",Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:05Z,,0,0,09000064b92c4a33 EPA-HQ-OAR-2025-0618-0005,EPA,EPA-HQ-OAR-2025-0618,"Letter from J. Seitz, EPA/OAQPS to C. Williams, Minnesota Pollution Control Agency",Supporting & Related Material,Letter,2026-05-13T04:00:00Z,2026,5,,,2026-05-13T16:54:03Z,,0,0,09000064b92c4295